Proof-of-principle Basic Science/preclinical Proposals in the Field of Cancer Research

How to Apply: 

 In 2025, the Lotte & John Hecht Memorial Foundation will hold two rounds of competitions for proof-of-principle basic science/preclinical proposals in the field of cancer research. The Foundation is looking to support non-mainstream hypotheses and non-conservative projects which do not fit traditional funding mechanisms and have not received previous grants/awards. This opportunity is intended to attract emerging ideas which are high risk/-high reward and for which preliminary data is not required. Accordingly, proposal hypotheses must be based on extensive literature review and logical substantiation.  

Proposals may originate from young or established researchers within their field of expertise or may be inspired by innovations and discoveries from adjacent or non-related areas, including further exploration of collateral findings discovered ‘by accident’, and/or other methods.  For illustration purposes, consider well known projects such as the ‘grapefruit effect’ (Dr. David Bailey), H. pylori and gastritis & peptic ulcer (Dr. Robin Warren), mRNA-based gene therapy (Dr. Katalin Kariko), and the discovery of an RNA catalytic function (Dr. Thomas Cech) as examples of novel discovery.  

We invite applications from Canadian qualified donees, including both single- and multi-investigator teams. Proposals will be evaluated based on novelty and feasibility. 

This award will cover up to $450,000 per project over three years, with the possibility of extension and renewals.

External Deadline: 
Tuesday, April 15, 2025
Funding Source: 
External
Funding Level: 
Research

Lotte & John Hecht Memorial Foundation

Call for Concept Notes – Health, Education and Women's and Girls’ Rights and Empowerment in Afghanistan

How to Apply: 

The call will fund projects that support the delivery of basic needs services to Afghans, especially women and girls, in one or more of the following three programming areas:

  1. Quality, accessible, gender-responsive health services for the most marginalized (including women and girls in all their diversity, persons with disabilities, ethnic minorities, older persons, and other marginalized groups).
  2. Demand-driven skills training, particularly for women and girls in all their diversity, in areas such as literacy and numeracy, digital skills, life skills, business skills, and other relevant technical and vocational skill areas.
  3. Inclusive services that protect and advance the rights and empowerment of all Afghans, with a focus on gender, ethnic and religious minorities, underserviced populations including those impacted by disability, and support to women-led groups.
 
As an organization can only submit up to two proposals to this call, if a team is interested in applying to this opportunity, they are asked to contact the Office of Research (ahacquo1@lakeheadu.ca) no later than March 3, 2025 to indicate their interest.
External Deadline: 
Wednesday, April 2, 2025
Funding Source: 
External
Funding Level: 
Research

New Grand Challenges

How to Apply: 

Innovations for Gram-Negative Antibiotic Discovery

The ultimate objective of Gr-ADI will be to enable discovery of safe and simple first-line broad-spectrum drugs for syndromic management, through:

  • Development of novel and emerging biological, chemical, and AI tools that could be applied broadly for antibiotic discovery to identify new antibiotic targets.
  • Application of these innovative approaches to generate chemical starting points for project-based drug discovery.
  • Fostering a collective mindset to address gaps in knowledge, solve problems, and manage a portfolio of targets and hits.
 

Accelerating Innovations to Address Heavy Menstrual Bleeding in Women in Low-Resource Settings

We invite research proposals on HMB based on the clinical definition that focus on:

  1. Biological Mechanisms – Advancing understanding of the fundamental biology of HMB to identify targets for innovative diagnostics and treatments.
  2. Epidemiology and Impact – Assessing disease burden, patterns, and impact on gynecological health and quality of life in women in low-resource settings.
  3. Measurement and Standardization – Developing and validating improved methods for measuring HMB and establishing standardized research protocols to enable consistent and comparable studies across diverse populations and healthcare systems.
  4. Innovative Diagnostics – Proposing new technology or piloting the use of existing technology to identify causes of HMB in low resource settings, including the use of artificial intelligence. Technology should be easy to use and affordable.
  5. Treatment and Access – Evaluating the effectiveness, acceptability, and ways to increase access to treatment including hormonal contraceptives, to inform patient-centered care in low-resource settings.

 

Enhancing HIV and TB Diagnosis: Adjunct Technologies for Sample Collection and Processing

Recent improvements in diagnostic testing have enabled molecular and lateral flow testing to be performed closer to the patient than ever and in some cases at home with a fully consumable test format. The challenge lies in developing solutions upstream to testing that enable easier, more affordable, and self-administered sample collection, sample preparation, and lysis when needed to support innovative PoC tests with faster turnaround times.

"Enhancing HIV and TB Diagnosis: Adjunct Technologies for Sample Collection and Processing"

Specifically, the objectives of this challenge will be to address one, or all, of the following:

  1. Self-Sample Blood Collection Devices (Phlebotomist-free blood collection)
    1. Solutions must enable phlebotomist-free collection of at least 1 mL of whole blood with performance comparable to phlebotomist-collected samples. Key parameters include sample quality, volume collected, failure rate, and ease of use.
    2. Solutions must ensure that the sample is stable for at least 24 hours at temperatures up to 40°C and humidity up to 70% without the need for cold chain.
    3. Ideally, the solution should be compatible with serum or plasma generation but must, at minimum, enable robust whole blood collection.
    4. If a design includes a sample collection or container component (e.g., a tube or cup), the storage device must prevent leakage and/or aerosolization of contents during storage and transportation.
    5. If a design includes a buffer, it must be compatible with downstream immunoassay or nucleic acid amplification and detection without need for extraction or purification.
    6. Solutions developed must be simple enough for use at home by a layperson or by a low-level healthcare worker.
  2. Sample Collection for MTB
    1. Solutions must enable collection of reproducibly consistent specimen biomass that does not require pipetting.
    2. If a design includes a sample collection or container component (e.g., a tube or cup), the storage device must prevent leakage and/or aerosolization of contents during storage and transportation.
    3. If a design includes a buffer, it must be compatible with downstream lysis and nucleic acid amplification and detection without need for extraction or purification.
    4. Samples must be stable for up to 72 hours at temperatures up to 40°C and humidity up to 70% without the need for cold chain.
    5. Solutions must be safe for administration and simple enough for home use by a layperson or low-level healthcare worker.
  3. Sample Preparation Devices (Instrument-free sample processing) for HIV detection
    1. Sample preparation solutions could include single or multiple sample processing aspects such as sample clean up, filtration, plasma/serum generation, analyte concentration, etc.
    2. If sample preparation is integrated with sample collection, the processing step (e.g., plasma/serum separation) should be seamless and included in the collection workflow.
    3. If sample preparation includes stabilization, specifically for RNA targets, solutions should enable sample stabilization for at least 24 hours or more at temperatures up to 40°C and humidity up to 70% without the need for cold chain. The samples must also meet performance equivalence to fresh samples (TSS 1 - Human immunodeficiency virus (HIV) rapid diagnostic tests for professional and/or self-testing).
    4. Ideally, no additional instruments should be required to complete the steps. However, if any are necessary, they must be compact, easily transportable, battery-powered, and cost-effective (under $50 USD).
    5. The solution must be simple and safe enough to be performed at home by a lay user or by a low-level health care worker.
  4. Sample Lysis Devices (Instrument-free lysis) for TB lysis
    1. Novel devices must demonstrate feasibility of MTB cell inactivation (by standard biosafety analysis protocols) and lysis (as compared to mechanical lysis via bead beating or sonication) without the need for a reusable instrument. (New Manual Quantitative Polymerase Chain Reaction Assay Validated on Tongue Swabs Collected and Processed in Uganda Shows Sensitivity That Rivals Sputum-based Molecular Tuberculosis Diagnostics).
    2. The solution must break open the MTB cells (>50% lysis efficiency compared to mechanical lysis via bead beating or sonication) without damaging target DNA.
    3. The resulting lysate must be stable for up to 72 hours at temperatures up to 40°C and humidity up to 70% without the need for cold chain.
    4. Ideally, no additional instruments should be required to complete the steps. However, if any are necessary, they must be compact, easily transportable, battery-powered, and cost-effective (under $50 USD).
    5. The solution must be simple and safe enough to be performed at home by a lay user or by a low-level health care worker. 
  5. Sample Clean up and Analyte Concentration
    1. Pre analytical solutions to improve analyte quality for improved assay performance including but not limited to sample clean up, analyte concentration, and interference removal.
    2. The solution must demonstrate equivalence with laboratory sample clean up methods and analyte concentration kits.
       
 

Innovative Data and Modeling Approaches to Measure Women's Health

We invite applicants to explore bold, innovative approaches. Specifically, the objectives of the Challenge will be to:

  • Reimagine new ways to understand and measure women's health that extend beyond the limitations of existing composite indicators such as DALY.
  • Use existing data sets or easily collectible datasets to quantify women's health outcomes across countries. While this Grand Challenge does not fund large-scale data collection, proposals may include small-scale data expansion where it is feasible, policy-relevant, and significantly enhances gendered analysis.
  • Design innovative methodologies that incorporate gendered, socio-cultural, economic, and structural determinants of health, ensuring a comprehensive gender-sensitive approach (A gender-sensitive approach takes into consideration how one's gender impacts access to services, risk and protective factors and barriers that are uniquely experienced because of one's gender in a society).
  • Create tools or frameworks that enable cross-cultural or subnational comparative analysis, identifying context-specific gaps and progress.
  • Reflect the interconnected dimensions of women's health across the life course
  • Incorporate gaps in the measurement of:
    • Skills, knowledge, and networks: addressing how gender disparities in education, training, and professional networks impact health access, decision-making, and service delivery.
    • Supply and access to services: examining how health systems, financing mechanisms, and gender-based barriers affect the availability, affordability, and accessibility of essential services for women
    • Health and economic impacts: capturing the intersection of health outcomes with economic participation, caregiving burdens, workforce inclusion, and financial independence.
  • Produce outputs that are:
    • Methodologically rigorous: applying sound data science, statistical modeling, or analytical techniques that enhance the validity and reliability of women's health measurements.
    • Interpretable and actionable: ensuring results can be understood and applied by policymakers and implementers.
    • Comparative and scalable: enabling cross-cultural or subnational analysis to identify patterns, disparities, and opportunities for intervention.
    • Gender-sensitive and intersectional: incorporating the social, economic, and structural determinants that affect women's health outcomes.
    • Policy-relevant and decision-oriented: providing insights that have the potential to directly inform policies, resource allocation, or program design to improve women's health measurement and action.

Reducing the Burden of Preeclampsia

We seek proposals for innovative solutions for the early detection, prevention, and treatment of preeclampsia, particularly in low- and middle-income countries where maternal mortality rates are high. To support this focus, we are looking for collaborations, including those with research institutions, health care providers, and global health organizations, that enable cross-sector insights and ensure that solutions are adaptable and practical.

The objectives of the challenge are:

  1. Early prediction and detection of preeclampsia. We seek biomarkers (including other than sFlt1 and PlGF), diagnostic tests, and point-of-care technologies to predict early in pregnancy the risk of preeclampsia and to diagnose it before symptoms become severe.
  2. Understanding the pathophysiology of preeclampsia and its heterogeneity. We seek to understand the biological mechanisms driving the disease and its subtypes so that new interventions can be effectively tailored to the underlying etiology.
  3. Preventive and therapeutic interventions. We seek new approaches to known targets or new targets to reduce the incidence and severity of preeclampsia, mitigate disease progression, and prevent the cardiovascular and metabolic complications that often follow it.
External Deadline: 
Tuesday, March 25, 2025
Funding Source: 
External
Funding Level: 
Research

Academics Without Borders

Collaborative Research and Training Experience (CREATE) program

How to Apply: 

NSERC's Collaborative Research and Training Experience (CREATE) program supports the training and mentoring of teams of highly qualified students and postdoctoral fellows from Canada and abroad through the development of innovative training programs that:

  • encourage collaborative and integrative approaches, and address significant scientific challenges associated with Canada’s research priorities, and 

  • facilitate the transition of new researchers from trainees to productive employees in the Canadian workforce

For this year's competition, the NSERC CREATE program will still include the regular and international streams (as in the past, the international stream is linked to the German research foundation, the Deutsche Forschungsgemeinschaft (DFG)). The 2026 CREATE competition will also involve a special theme area related to genomics.

Even though NSERC CREATE Letters of Intent (LOIs) will no longer be adjudicated and will proceed directly to the full application stage, the CREATE program for the 2026 competition year has been modified as follows: even though an unlimited number LOIs can be submitted by an institution, the LOI stage will be semi-competitive. NSERC will admit, via peer review using established criteria, a specific number of LOIs from each institution to the application stage. Lakehead's allotment for the present competition is one LOI (international stream and up to two genomics-related LOIs will not count towards this allotment). Only when an institution submits a number of LOIs greater than their allotment will their LOIs be evaluated to determine which LOI (in Lakehead's case) will advance to the application stage. As well, NSERC has established that the total number of new CREATE grants that can be awarded to an institution is capped at 3 per competition year.

If you intend to submit an LOI to this program, you  must notify the Office of Research Services (ahacquo1@lakeheadu.ca) by March 3, 2025 of your intention to apply to this opportunity.     If more than one team indicates that they are submitting an LOI to the CREATE program (again, under the regular stream (non-genomics)), an internal competition will need to be held to determine which LOI may be considered for submission to NSERC. If it is determined that an internal competition needs to be held, further information on the specific materials that are required to be submitted by internal applicants will be provided at that time.

Given the highly competitive nature of the NSERC CREATE program and the requirement for institutional support, Principal Investigators will be required to work closely with assigned research facilitators from the conceptualization of the project proposal to final submission (this includes seeking support from co-applicant institutions)Please note that the NSERC CREATE guidelines and LOI form have not yet been updated by NSERC.  This is expected to happen by Mid March.

External Deadline: 
Thursday, May 1, 2025
Funding Source: 
External
Funding Level: 
Research

ACS Petroleum Research Fund

How to Apply: 

The Petroleum Research Fund is an endowed fund, managed by the American Chemical Society that supports fundamental research directly related to petroleum or fossil fuels at nonprofit institutions (generally colleges and universities) in the United States and other countries.

ACS Petroleum Research Fund (ACS PRF) grants are intended as seed money, to enable an investigator to initiate a new research direction. The investigator should not have published or received financial support from another funding agency for the proposed research. Also, proposals that the ACS PRF Committee feels are a logical extension of an investigator’s previous research may be denied as “not a new direction.”

Scope of the Fund

Proposals must be for fundamental research in “the petroleum field,” which is defined in our founding document as “petroleum, natural gas, coal, shale, tar sands and like materials.” Fundamental research encompasses the properties of these materials, whereas the petroleum industry undertakes “applied research,” which is outside the scope of ACS PRF. However, please note that while the PRF Trust imposes certain restrictions, PRF currently funds many topics of current interest in sustainability and green chemistry. These include, for example, new catalysts and upgrading/utilization of methane and carbon dioxide.

External Deadline: 
Friday, March 7, 2025
Funding Source: 
External
Funding Level: 
Research

Climate Change and Human Health Seed Grants

How to Apply: 

The Burroughs Wellcome Fund aims to stimulate the growth of new connections between thinkers working in largely disconnected fields who might together change the course of climate change’s impact on human health. In the three years between Fall 2023 and Summer 2026, we will dedicate $1M to supporting small, early stage grants of $2,500–$50,000 toward achieving this goal.

We are mainly but not exclusively interested in activities that build connections between basic/early biomedical scientific approaches and ecological, environmental, geological, geographic, and planetary-scale thinking, as well as with population-focused fields, including epidemiology and public health, demography, economics, and urban planning. Also of interest is work piloting new approaches or interactions toward reducing the impact of health-centered activities, such as developing more sustainable systems for health care, care delivery, and biomedical research systems.

External Deadline: 
Thursday, April 24, 2025
Funding Source: 
External
Funding Level: 
Research

Global Affairs Canada Scholarships (inbound - ELAP and SICS) 2025-2026

How to Apply: 

Global Affairs Canada has opened its call for international scholarship applications for the 2025-26 academic year.  Researchers may be contacted by students from eligible countries seeking a supervisor for a research stay. 

There are scholarships for STUDY (usually undergrads) and RESEARCH (usually graduate students). Students cannot apply directly and must be nominated by their home institutions; applications are submitted by Lakehead University, with selection decisions made by Global Affairs Canada.  

Please note that visiting research students are expected to work on their research full-time for 4-6 months under the Lakehead researcher's supervision.

ELAP - Emerging Leaders of the Americas Internal Deadline: March 6 (External March 18)

  • Caribbean: Anguilla, Antigua and Barbuda, Bahamas, Barbados, Belize, Bermuda, British Virgin Islands, Cayman Islands, Cuba, Dominica, Dominican Republic, Grenada, Guyana, Haiti, Jamaica, Montserrat, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Suriname, Trinidad and Tobago, Turks and Caicos;
  • Central America: Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama;
  • North America: Mexico;
  • South America: Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Paraguay, Peru, Uruguay, Venezuela.

SICS - Study in Canada Scholarship - Internal Deadline: March 6 (External March 18)

  • Asia: Bangladesh, Nepal, Taiwan;
  • Europe: Türkiye, Ukraine;
  • Middle East and North Africa: Algeria, Egypt, Jordan, Morocco, Tunisia;
  • Sub-Saharan Africa: Burkina Faso, Ethiopia, Ghana, Ivory Coast, Kenya, Nigeria, Rwanda, Senegal, Tanzania, Uganda.

IMPORTANT - The students' home institution may have internal selection processes/competitions and earlier deadlines as well.

To be eligible, study students must be from institutions where Lakehead has an MOU / Exchange agreement. For research students, an MOU is not mandatory.  In a few cases, an undergrad may be nominated for a research stay if the Lakehead researcher has a genuine collaboration with the student's home institution.

For questions, please contact Jill Sherman at intl.research@lakeheadu.ca.

External Deadline: 
Tuesday, March 18, 2025
Funding Source: 
External
Funding Level: 
Doctoral
Masters
Research
Undergraduate

Global Affairs Canada Scholarships (SEED - In-bound) Canada-ASEAN Scholarships and Educational Exchange for Development

How to Apply: 

Global Affairs Canada has opened its call for applications to its international scholarship programs for the 2025-26 academic year.  Researchers may be contacted by students from eligible countries seeking a supervisor for a research stay. 

There are scholarships for STUDY (usually undergrads) and RESEARCH (usually graduate students). Students cannot apply directly and must be nominated by their home institutions; applications are submitted by Lakehead University, with selection decisions made by Global Affairs Canada.

If researchers are interested in hosting a visiting research student and have research collaborators in any of the eligible countries, they are encouraged to reach out and invite applications from their students. Please note that VRS are expected to work on their research full-time during their stay, under the Lakehead researcher's supervision.

 

SEED - Canada-ASEAN Scholarships and Educational Exchange for Development - Internal Deadline March 19 (External March 31).

Please note that this year, the SEED program has changed - maximum length of stay is 4 months and must start no later than October 1, 2025.

  • for citizens of ASEAN member states (Brunei Darussalam, Cambodia, Indonesia, Laos (Lao People’s Democratic Republic (Lao PDR)), Malaysia, Myanmar, The Philippines, Singapore, Thailand, or Vietnam)

IMPORTANT - The students' home institution may have internal selection processes/competitions and earlier deadlines as well.

To be eligible, study students must be from institutions where Lakehead has an MOU / Exchange agreement. For research students, an MOU is not mandatory.  In a few cases, an undergrad may be nominated for a research stay if the Lakehead researcher has a genuine collaboration with the student's home institution.

For questions, please contact Jill Sherman at intl.research@lakeheadu.ca.

External Deadline: 
Monday, March 31, 2025
Funding Source: 
External
Funding Level: 
Doctoral
Masters
Research
Undergraduate

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