Proof-of-principle Basic Science/preclinical Proposals in the Field of Cancer Research
In 2025, the Lotte & John Hecht Memorial Foundation will hold two rounds of competitions for proof-of-principle basic science/preclinical proposals in the field of cancer research. The Foundation is looking to support non-mainstream hypotheses and non-conservative projects which do not fit traditional funding mechanisms and have not received previous grants/awards. This opportunity is intended to attract emerging ideas which are high risk/-high reward and for which preliminary data is not required. Accordingly, proposal hypotheses must be based on extensive literature review and logical substantiation.
Proposals may originate from young or established researchers within their field of expertise or may be inspired by innovations and discoveries from adjacent or non-related areas, including further exploration of collateral findings discovered ‘by accident’, and/or other methods. For illustration purposes, consider well known projects such as the ‘grapefruit effect’ (Dr. David Bailey), H. pylori and gastritis & peptic ulcer (Dr. Robin Warren), mRNA-based gene therapy (Dr. Katalin Kariko), and the discovery of an RNA catalytic function (Dr. Thomas Cech) as examples of novel discovery.
We invite applications from Canadian qualified donees, including both single- and multi-investigator teams. Proposals will be evaluated based on novelty and feasibility.
This award will cover up to $450,000 per project over three years, with the possibility of extension and renewals.