he FY21 Defense Appropriations Act is anticipated to provide funding to the Department of Defense PRARP to support research that addresses the long-term implications of military service as they pertain to Alzheimer’s disease (AD) and related dementias (ADRD) for Service members, Veterans, and the general public.  As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation.  The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).

FY21 PRARP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website. 

Applications submitted to the FY21 PRARP Program Announcements must address one of the following FY21 Overarching Challenges, which may be award mechanism-specific:

In addition to addressing one of the specified FY21 Overarching Challenges, applications must also address one or more of the following FY21 Military Risk Factors in support of the FY21 Overarching Challenges. 

The PRARP FY21 Military Risk Factors are listed below.

The following is a summary of the FY21 PRARP Program Announcements.  Five award mechanisms will be offered for FY21. 

https://cdmrp.army.mil/funding/prarp

Convergence Science Research Award (CSRA) – Letter of Intent due June 14, 2021

Level I: Investigators at the postdoctoral level (e.g., research associates, fellows, medical residents, or equivalent) but below the level of Assistant Professor (or equivalent) at the time of the application submission deadline.

 Mentor required.

Level II: The Principal Investigator (PI) must be an independent investigator at or above the level of Assistant Professor (or equivalent) at the time of the application submission deadline.

Intent: To support innovative and impactful efforts to generate research resources, tools, and new avenues of investigation for researchers and practitioners in the health sciences.

 Level I: Applicant can be from any field or discipline and must write the project narrative and other application components, with appropriate guidance from the mentor(s). The mentor(s) must possess qualifications, background, and experience in both the identified military risk factor and Alzheimer’s disease (AD)/AD-related dementias (ADRD) research.

 Level II: Intended to support applicants from any field or discipline at or above the level of assistant professor (or equivalent) from any field or discipline. Study teams are expected to demonstrate relevant experience in both the identified military risk factor and AD/ADRD.

Applications must address one of the following FY21 PRARP Overarching Challenges:

 Foundational Research

 Paucity of Clinical Studies

 Diagnostics and Prognostics

 Epidemiology

Applications should address one of the following FY21 PRARP Military Risk Factors:

 Traumatic Brain Injury

 Neurophysiological/Neurobehavioral

 Vascular

 Inflammation

 Genetic

Metabolic

 Sleep

Pharmacological interventions are specifically discouraged.

While not required, applications to either Funding Level I or II are encouraged to provide relevant preliminary data.

Research that focuses exclusively on chronic traumatic encephalopathy (CTE) research is prohibited.

Pharmacological interventions are specifically discouraged.

Chronic traumatic encephalopathy (CTE) research is prohibited.

Preliminary data, while not required, are encouraged.

Level I:

 Maximum funding of $225,000 for direct costs (plus indirect costs).

 Maximum period of performance is 3 years.

Level II:

 Maximum funding of $500,000 for direct costs (plus indirect costs).

 Maximum period of performance is 3 years.

For Both Levels:

Indirect costs may be proposed in accordance with the institution’s rate agreement.

Innovation in Care and Support Award (InCASA) – Letter of Intent due June 14, 2021

Level I: Investigators at the postdoctoral level (e.g., research associates, fellows, medical residents, or equivalent) but below the level of Assistant Professor (or equivalent) at the time of the application submission deadline.

 Mentor required.

Level II: The PI must be an independent investigator at or above the level of Assistant Professor (or equivalent) at the time of the application submission deadline.

Intent: To support innovative and impactful research that improves the quality of life and care for individuals, families, and care providers living with AD/ADRD.

 Level I: Applicant can be from any field or discipline and must write the project narrative and other application components, with appropriate guidance from the mentor(s). The mentor(s) must possess qualifications, background, and experience in both the identified military risk factor and AD/ADRD.

 Level II: Intended to support applicants from any field or discipline at or above the level of assistant professor (or equivalent) from any field or discipline. Study teams are expected to demonstrate relevant experience in both the identified military risk factor and AD/ADRD.

Applications must address one of the following FY21 PRARP Overarching Challenges:

 Paucity of Clinical Studies

 Quality of Life

 Family and Care Support

Applications should address one of the following FY21 PRARP Military Risk Factors:

 Traumatic Brain Injury

 Neurophysiological/Neurobehavioral

 Modifiable Risk Factors

 Vascular

 Inflammation

 Genetic

 Metabolic

 Sleep

Pharmacological interventions are specifically discouraged.

Animal research is prohibited.

While not required, applications to either Funding Level I or II are encouraged to provide relevant preliminary data.

Research that focuses exclusively on CTE research is prohibited.

Level I:

 Maximum funding of $225,000 for direct costs (plus indirect costs).

 Maximum period of performance is 3 years.

Level II:

 Maximum funding of $500,000 for direct costs (plus indirect costs).

 Maximum period of performance is 3 years.

For Both Levels:

Indirect costs may be proposed in accordance with the institution’s rate agreement.

Research Partnership Award (RPA) – Letter of Intent due June 14, 2021

The initiating PI must be an independent investigator at or above the level of Assistant Professor (or equivalent) at the time of the application submission deadline.

Each named Co-PI must be at or above the level of assistant professor (or equivalent) at the time of the application submission deadline.

Intent: To create an avenue for collaborative research partnerships between/among investigators to address a research problem or question in a manner that would be unachievable through separate efforts as related to the PRARP’s mission.

Applications must include clearly stated plans for interactions between/among the partners. The plans must include communication, decision-making, allocation of resources, coordination of research progress and results, and sharing of data among all investigators and organizations participating in the project.

Applications must address one of the following FY21 PRARP Overarching Challenges:

 Foundational Research

 Paucity of Clinical Studies

 Diagnostics and Prognostics

 Epidemiology

 Quality of Life

 Family and Care Support

Applications should address at least one of the following FY21 PRARP Military Risk Factors:

 Traumatic Brain Injury

 Neurophysiological/Neurobehavioral

 Modifiable Risk Factors

 Vascular

 Inflammation

 Genetic

 Metabolic

 Sleep

Pharmacological interventions are specifically discouraged.

Preliminary data to support the feasibility of the research hypothesis (or hypotheses) or objectives are required.

Research that focuses exclusively on CTE research is prohibited.

Funding limit is $1.3 million (M) in total costs.

 Maximum period of performance is 3 years.

 Indirect costs may be proposed in accordance with the institution’s rate agreement.

Accelerating Diagnostics Research Award (ADRA) – Letter of Intent due June 14, 2021

The PI must be an independent investigator at or above the level of Assistant Professor (or equivalent) at the time of the application submission deadline.

Intent: To support high-impact, human-based development of robust diagnostic and/or prognostic biomarkers for military risk factors that pertain to AD/ADRD.

Applications must address the following FY21 PRARP Overarching Challenge.

 Diagnostics and Prognostics

Applications must address one of the following FY21 PRARP Military Risk Factors:

 Traumatic Brain Injury

 Neurophysiological/Neurobehavioral

 Vascular

 Inflammation

 Genetic

 Metabolic

The proposed biomarker for investigation must correlate with clinical endpoints to include cognition and/or behavior relevant to the proposed military risk factor and AD/ADRD. The applicant must choose one biomarker category for the overall application:

 Imaging-Related

 Fluid-Based (e.g., cerebrospinal fluid, blood, or saliva)

 Retinal

 Wearable Devices

 Other

Studies focused on biomarker discovery are discouraged.

Pharmacological interventions are specifically discouraged.

Animal research is prohibited.

Preliminary data regarding the suitability of the biomarker(s) for further testing toward biomarker qualification is required.

Research that focuses exclusively on CTE research is prohibited.

Funding limit is $2.8M in total costs.

 Maximum period of performance is 4 years.

 Indirect costs may be proposed in accordance with the institution’s rate agreement.

Leveraging Approaches for Innovation in Care and Support Award (LEAP-InCASA) – Letter of Intent due June 14, 2021

The PI must be an independent investigator at or above the level of Assistant Professor (or equivalent) at the time of the application submission deadline.

Intent: To support high-impact, human-based development of robust diagnostic and/or prognostic biomarkers for military risk factors that pertain to AD/ADRD.

Applications must address the following FY21 PRARP Overarching Challenge.

 Diagnostics and Prognostics

Applications must address one of the following FY21 PRARP Military Risk Factors:

 Traumatic Brain Injury

 Neurophysiological/Neurobehavioral

 Vascular

 Inflammation

 Genetic

 Metabolic

The proposed biomarker for investigation must correlate with clinical endpoints to include cognition and/or behavior relevant to the proposed military risk factor and AD/ADRD. The applicant must choose one biomarker category for the overall application:

 Imaging-Related

 Fluid-Based (e.g., cerebrospinal fluid, blood, or saliva)

 Retinal

 Wearable Devices

 Other

Studies focused on biomarker discovery are discouraged.

Pharmacological interventions are specifically discouraged.

Animal research is prohibited.

Preliminary data regarding the suitability of the biomarker(s) for further testing toward biomarker qualification is required.

Research that focuses exclusively on CTE research is prohibited.

Funding limit is $2.8M in total costs.

 Maximum period of performance is 4 years.

 Indirect costs may be proposed in accordance with the institution’s rate agreement.

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline.  All applications must conform to the final Program Announcements and General Application Instructions available for electronic downloading from the Grants.gov website.  The application package containing the required forms for each award mechanism will also be found on Grants.gov.  A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420. 

For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org.  For more information about the PRARP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).

Point of Contact:

CDMRP Help Desk
301-682-5507
help@eBrap.org

On April 9, 2021 SHARCNET issued a call for proposals for Dedicated Programming Support Round XVIII. Applications are encouraged that satisfy the programme objectives and priority will be given to proposals that meet one or more of the following conditions:

• Propose an innovative project that will leverage the capabilities of the national systems, such as “Graham” and the cloud.
• Propose a programme of work that deals with the efficient processing of large, heterogeneous datasets using a variety of data mining, machine learning or other analytics software.

Applications are submitted via SHARCNET’s webportal and are due by May 21, 2021 at 11:59 pm EST. Please note that consultation with a SHARCNET HPTC prior to submission is a programme requirement.

Due to the current workload of SHARCNET programming staff, only a limited number of proposals are expected to be awarded in this round. For additional information, please refer to the application guidelines. Questions should be addressed to research-support@sharcnet.ca.

The objective of the Idea to Innovation (I2I) grants is to accelerate the pre-competitive development of promising technology originating from the university and college sector and promote its transfer to a new or established Canadian company. The I2I grants provide funding to college and university faculty members to support research and development projects with recognized technology transfer potential. This is achieved through defined phases by providing crucial assistance in the early stages of technology validation and market connection.

The specific objectives of this funding opportunity are:

• Support research on the current health issues experienced within OLMCs;
• Strengthen collaboration and partnerships among researchers and health organizations working with or within OLMCs (multi-institutional collaboration is encouraged);
• Develop and enhance the community-based research approach within OLMCs;
• Strengthen the knowledge mobilization approach amongst researchers to address the gaps on OLMC health;
• Build capacity in the area of OLMC health.

The goal of the Agricultural Climate Solutions Program (ACS) is to accelerate co-development, testing, adoption, dissemination and monitoring of technologies and practices, including beneficial management practices (BMPs), that sequester carbon and/or mitigate greenhouse gas (GHG) emissions.

Through a collaborative approach, projects will focus on the on-farm co-development, testing, adoption and monitoring of new BMPs and technologies. Projects funded under ACS will follow the living lab innovation model. A living lab is an integrated approach to agricultural innovation that brings together farmers, scientists, and other participants to co-develop, test, and monitor new BMPs and technologies in a real-life context where they will be used: on Canadian farms. More information about the living lab model and its core principles can be found in the Living Laboratories Initiative.

ACS will consider projects within the following 2 priority areas:

• Carbon sequestration (for example, cover crops, intercropping, conversion of marginal land to permanent cover, shelterbelts, inclusion of pulses in rotations)
• Greenhouse gas mitigation (for example, nutrient management, feeding strategies)

Please note that during the 2021-22 funding cycle, the emphasis will be on supporting proposals that include the advancement of carbon sequestration as an important part of their project activities.

In addition, projects should indicate if they could support the achievement of other relevant environmental benefits, such as:

• improving soil health and water quality
• water conservation
• increasing biodiversity
• maximizing habitat capacity

The aim of the 2021 grant funding is to facilitate establishing a Canada-wide network of living labs. Eligible organizations in all provinces are welcome to submit their applications for 2021 grant funding to support the preparation of proposals leading to the development of living labs in their province. Please note that while the 2021 granting process is open across the country, the focus will be placed on helping organizations in provinces that currently do not host a living lab established as part of the Living Laboratories Initiative - Collaborative Program (LLI-CP, 2018-23). Currently, provinces of Prince Edward Island, Quebec, Ontario and Manitoba each host a living lab under LLI-CP.

A second call for grant proposals will be offered in 2022.

Brain Canada is pleased to be partnering with Alzheimer’s Association (ALZ) to jointly launch the Advancing Research on Care and Outcome Measurement (ARCOM) funding program, an international and collaborative competition aimed at addressing the significant measurement gaps in care and outcomes across diverse and underrepresented populations and stages of dementia. This program will provide an exceptional opportunity for Canadian researchers to join the international research community and contribute to an underfunded area of focus to help ensure care providers are implementing evidence-based practices and achieving desired outcomes. Through this partnership, Brain Canada is committing up to the equivalent of $750,000 CAD to Canadian-led teams who meet peer review recommendations.

The FY21 Defense Appropriations Act is anticipated to provide funding to the Department of Defense OPORP to support supports research that evaluates orthoses and/or prostheses using patient-centric outcomes relevant to Service Members and military beneficiaries, Veterans, and other individuals with limb loss and/or limb impairment.  As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation.  The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).

FY21 OPORP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website. 

The vision of the OPORP is to ensure the highest possible quality of life for our injured Service members, Veterans, and beneficiaries through the advancement of knowledge in orthotics- and prosthetics-related practice.  The OPORP supports research on outcomes-based best practices through analysis of prosthetic and/or orthotic device options that are currently available, and not on the development of new devices or the improvement of an existing technology. Projects involving spinal orthoses, pediatric populations, or analysis of short-term use devices will not be considered for the FY21 OPORP.

Applications submitted to the FY21 OPORP must address one or more of the following focus areas:

• Orthoses or Prostheses Form:  Optimize patient outcomes through the analysis and characterization of variables related to the form of currently available clinical options such as device size, shape, material, and/or configurations.

• Orthoses or Prostheses Fit:  Optimize patient outcomes related to the human-device interface through the analysis of variables in currently available clinical options that facilitate fit-related metrics such as comfort, limb health, and/or usability.

• Orthoses or Prostheses Control:  Optimize patient outcomes through the analysis of variables related to currently available device mechanisms such as device control, sensors, and passive or active response.

• Orthoses or Prostheses Function:  Optimize patient outcomes by analyzing device-inclusive care protocols and interventions to inform best practices such as evaluation and prescription, timing of interventions, community functioning, and multidisciplinary approaches to clinical care in order to understand short- and long-term outcomes with respect to activities of daily living and other real-world activities.

https://cdmrp.army.mil/funding/oporp

Clinical Research Award – Letter of Intent due July 15, 2021

Independent investigators at all academic levels (or equivalent)

Supports research that evaluates orthoses and/or prostheses using patient-centric outcomes relevant to Service Members, Veterans, and other individuals with limb loss and/or limb impairment.

 Supported research is intended to generate clinically useful evidence with potential to enhance and optimize patient outcomes, and inform clinical or policy decisions.

 Multidisciplinary collaboration among academia, industry, patient advocacy, the military Services, the Department of Veterans Affairs (VA), and/or other federal government agencies is highly encouraged.

 Applications submitted to the FY21 OPORP CRA must address at least one of the FY21 OPORP Focus Areas.

 Preclinical studies using animals are not allowed.

 Clinical trials are not allowed.

The FY21 OPORP CRA offers two funding levels:

Funding Level 1:

 Maximum funding of $350,000 for total costs (direct costs plus indirect costs)

 Maximum period of performance is 2 years

Funding Level 2:

 Maximum funding of $2,000,000 for total costs (direct costs plus indirect costs)

 Maximum period of performance is 4 years

Clinical Trial Award – Letter of Intent due July 15, 2021

Independent investigators at all academic levels (or equivalent)

 Supports implementation of clinical trials with the potential to have a significant impact on improving the health and well-being of Service Members and military beneficiaries, Veterans, and other individuals with limb loss and/or limb impairment.

 Supports clinical trials that evaluate orthoses and/or prostheses using patient-centric outcomes for the purpose of generating clinically useful evidence to enhance and optimize patient outcomes.

 Multidisciplinary collaboration among academia, industry, patient advocacy, the military Services, VA, and/or other federal government agencies is highly encouraged.

 Applications submitted to the FY21 OPORP CTA must address at least one of the FY21 OPORP Focus Areas.

 Preclinical studies using animals are not allowed.

The FY21 OPORP CTA offers two funding levels:

Funding Level 1:

 Maximum funding of $350,000 for total costs (direct costs plus indirect costs)

 Maximum period of performance is 3 years

Funding Level 2:

 Maximum funding of $4,000,000 for total costs (direct costs plus indirect costs)

 Maximum period of performance is 4 years

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline.  All applications must conform to the final Program Announcements and General Application Instructions available for electronic downloading from the Grants.gov website.  The application package containing the required forms for each award mechanism will also be found on Grants.gov.  A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420. 

For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org.  For more information about the OPORP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).

Point of Contact:

CDMRP Help Desk
301-682-5507
help@eBrap.org

The FY21 Defense Appropriations Act provides funding to the Department of Defense Peer Reviewed Orthopaedic Research Program (PRORP) to support high-impact, clinically-relevant research to advance optimal treatment and rehabilitation from musculoskeletal injuries. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation.  The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).

The FY21 PRORP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website. 

Applications submitted to the FY21 PRORP must address one or more of the following focus areas:

• Compartment Syndrome: Novel treatment strategies to improve current diagnoses for compartment syndrome. Alternatives to intracompartmental pressure measurements are encouraged.
• Limb Stabilization and Protection: Development of rapid limb stabilization and novel wound protectants for severely or critically wounded limbs to enable prolonged care and eventual transport to the point of definitive treatment.
• Osseointegration: Identification of best practices to address infection, rejection, and/or failure of percutaneous osseointegrated prosthetic limbs.
• Prosthetic and Orthotic Devices: Development of high-performance novel prosthetic or orthotic devices designed to enhance whole person performance and decrease pain in patients with amputation and limb salvage, and impairment. Multicenter studies which focus on transfemoral amputees are encouraged.
• Retention Strategies: Development, optimization, and/or validation of battlefield-feasible diagnostic capabilities, decision support tools, interventions, and/or rehabilitation strategies that can facilitate retention on duty for common combat-related musculoskeletal injuries.  Biomarker studies are excluded. The current standard of care must be noted. The rehabilitation strategy to be used in the proposed study must be specified, as applicable.
  • Battlefield Care: Strategies that can be utilized at or near the point of injury to allow an injured Service member to remain on the battlefield or on mission without the need for evacuation. Treatment strategies that allow return to mission effectiveness within 30 days will be considered.
  • Return to Duty: Treatment strategies that can be utilized along the continuum of care and enable return to duty of the Service member within one year of injury.
• Tissue Regeneration Therapeutics: Development of advanced tissue regeneration therapeutics in nerve, muscle, and/or composite tissue for the restoration of traumatically injured extremities. Isolated bone or cartilage tissue engineering studies are excluded. Early clinical feasibility studies involving volumetric muscle loss are encouraged.
• Translation of Early Findings: Translation of early research findings in the orthopaedic surgical care topic areas listed below to move the research toward clinical trials and clinical practice.
  • Soft Tissue Trauma: Strategies to develop and/or identify musculoskeletal extremity soft tissue trauma treatments for shoulder, knee, or chronic ankle instability and sequela only, to optimize return to duty, work, or reintegration.
  • Fracture-Related Infection: Strategies to decrease the burden of fracture-related infections (may include prevention, early detection, or improved eradication). Alternatives to systemic antibiotic delivery are encouraged. Novel approaches that improve the current standard of treatment to prevent fracture-related infections are encouraged. 

https://cdmrp.army.mil/funding/prorp

Applied Research Award – Preproposal due May 27, 2021

Independent investigators at all academic levels (or equivalent)

Supports applied research applications focused on advancing optimal treatment and restoration of function for individuals with musculoskeletal injuries sustained during combat, combat-related activities, and non-battle injuries that impact unit readiness and the ability to return to duty/work.

• Proposed research should be supported by preliminary and/or published data and have the potential to make significant advancements toward clinical translation.

• Clinical research and clinical trials are not allowed under this award mechanism.

• Applications must address one of the following FY21 PRORP ARA Focus Areas:

○ Limb Stabilization and Protection

○ Retention Strategies

− Battlefield Care

− Return to Duty

○ Osseointegration

• Pre-application submission is required; application submission is by invitation only.

The maximum allowable funding for the entire period of performance is $725,000 for total costs.

• Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.

• The maximum period of performance is 3 years.

Clinical Trial Award – Preproposal due May 27, 2021

Independent investigators at all academic levels (or equivalent) are eligible to submit applications.

•Supports rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of military combat-related orthopaedic injuries or non-battle injuries that significantly impact unit readiness and return to duty/work rates.

•Investigational New Drug or Investigational Device Exemption applications, if needed, should be submitted to the Food and Drug Administration within 6 months of the award date.

•Applications must address one of the following FY21 PRORP CTA Focus Areas:

○Limb Stabilization and Protection

○Retention Strategies

−Battlefield Care

−Return to Duty

○Translation of Early Findings

−Soft Tissue Trauma

−Fracture-Related Infection

•Applications submitted to address the Translation of Early Findings – Soft Tissue Trauma Focus Area and include the Rehabilitation Option are eligible for Research Level 2.

•All applications, regardless of the selected Focus Area, are eligible for Research Level 1.

•Funding must support a clinical trial and may not be used for animal or preclinical research studies.

•Pre-application submission is required; application submission is by invitation only.

Research Level 1:

•The maximum allowable funding for the entire period of performance is$2.25 million (M) for total costs.

•Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.

•The maximum period of performance is 4 years.

Research Level 2:

•The maximum allowable funding for the entire period of performance is$2.75M for total costs.

•Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.

•The maximum period of performance is 4 years.

Clinical Translational Research Award – Preproposal due May 27, 2021

Independent investigators at all academic levels (or equivalent)

•Supports high-impact and/or new/emerging clinical research that may or may not be ready for a full-scale randomized controlled clinical trial.

•Funding must support clinical research studies involving humans.

•Preliminary data relevant to the proposed research project are required.

•Investigational New Drug or Investigational

Device Exemption applications, if needed, should be submitted to the Food and Drug Administration within 12 months of the award date

•Applications must address one of the following FY21 PRORP CTRA Focus Areas:

○Retention Strategies

−Battlefield Care

−Return to Duty

○Tissue Regeneration Therapeutics

○Compartment Syndrome

○Osseointegration

○Prosthetic and Orthotic Devices

•Pre-application submission is required; application submission is by invitation only.

•The maximum allowable funding for the entire period of performance is$1.5M for total costs.

•Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.

•The maximum period of performance is 4 years

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline.  All applications must conform to the final Program Announcements and General Application Instructions available for electronic downloading from the Grants.gov website.  The application package containing the required forms for each award mechanism will also be found on Grants.gov.  A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420. 

For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org.  For more information about the PRORP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).

Point of Contact:

CDMRP Help Desk
301-682-5507
help@eBrap.org

The FY21 Defense Appropriations Act is anticipated to provide $8M to the Department of Defense TSCRP to support innovative, high-impact tuberous sclerosis complex (TSC) research.  As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation.  The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).

FY21 TSCRP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website. 

Applications submitted to the FY21 TSCRP are encouraged to address one or more of the following Focus Areas:

• Eradicating tumors associated with TSC and TSC-associated lymphangioleiomyomatosis (LAM), including gaining a deeper mechanistic understanding of TSC signaling pathways
• Preventing epilepsy, improving treatment, and mitigating neurodevelopmental outcomes associated with TSC-related seizures
• Understanding the features of TSC-Associated Neuropsychiatric Disorders (TAND) and reducing their impact, including pharmacological and behavioral interventions

https://cdmrp.army.mil/funding/tscrp

Exploration – Hypothesis Development Award – Letter of Intent due June 17, 2021

Investigators at all academic levels (or equivalent), including postdoctoral fellows

• Supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the tuberous sclerosis complex (TSC) research field.
• Projects involving human subjects or human biological substances must be exempt under Title 32 of the Code of Regulations, Part 219.104(d) (32 CFR 219.104(d)) or eligible for expedited review under  21 CFR 56.110.
• Preliminary data are not required.
• Clinical trials are not allowed.
• The maximum allowable funding for the entire period of performance is $150,000 in direct
• Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.
• The maximum period of performance is 2 years

Idea Development Award – Letter of Intent due June 17, 2021

Established Investigators: Independent investigators at or above the level of Assistant Professor (or equivalent);

or

New Investigators:  Independent investigator at or below the level of Assistant Professor (or equivalent); or Established Investigator in an area other than TSC at or above the level of Assistant Professor seeking to transition to a career in TSC

• Promotes ideas that have the potential to yield high-impact findings and new avenues of investigation.
• Preliminary data are expected.
• Clinical trials are not allowed.
• New Investigator Option supports the continued development of promising independent investigators that are early in their faculty appointments and/or the transition or established investigators from other research fields into career in TSC research.
• Applications from New Investigators and Established Investigators will be peer and programmatically reviewed separately.
• The maximum period of funding for the entire period of performance is $500,000 in direct costs
• Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.
• The maximum period of performance is 3 years

Clinical Translational Research Award – Letter of Intent due June 17, 2021

Independent investigators at or above the level of Assistant Professor (or equivalent)

• Supports studies that will move promising, well-founded preclinical and/or clinical research findings closer to clinical application, including diagnosis, prognosis, or treatment of TSC.
• Applications may include correlative studies that are associated with a completed clinical trial.
• Supports studies advancing clinical trial readiness through development of biomarkers, clinical endpoints, and validation of PK/PD.
• Applications may include a small, pilot clinical trial intended to inform the next step in the continuum of translational research.
  • Preclinical studies may be appropriate but must include a clinical component.
  • Projects that are exploratory and/or strictly animal research will not be considered for funding.
  • Clinical Translational Potential is the most important review criterion.
  • Preliminary data are required.
  • The maximum allowable funding for the entire period of performance is $750,000 for direct costs
  • Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement
  • The maximum period of performance is 3 years

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline.  All applications must conform to the final Program Announcements and General Application Instructions that are available for electronic downloading from the Grants.gov website.  The application package containing the required forms for each award mechanism will also be found on Grants.gov.  A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420. 

For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org.  For more information about the TSCRP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).

Point of Contact:

CDMRP Help Desk
301-682-5507
help#@eBrap.org