Operating Grant : Emerging COVID-19 Research Gaps & Priorities July 2021
To be eligible to the competition, applications must address both objectives AND respond to one (1) of the eleven (11) specific research areas.
The specific objectives of this funding opportunity are:
- Accelerate the availability and use of high-quality and real-time evidence and/or solutions to support Canada’s ongoing response to the pandemic in order to better prevent, detect, treat and manage COVID-19; AND
- Generate evidence related to one or more marginalized population(s), including for instance: Black and other communities marginalized by race; First Nations, Inuit, Métis and Urban Indigenous Peoples; communities historically excluded from research; those experiencing health inequity; persons with disabilities and individuals across diverse health status (e.g. high risk populations, individuals with comorbid conditions); those experiencing gendered impacts of the pandemic; and those in life stages that have been underrepresented in research (e.g. pregnant people, children, older adults). Across all populations, researchers are encouraged to consider a lifecycle approach (from preconception to older adulthood).
Note: It is expected that, where appropriate, projects will enhance local, national and/or international collaborative efforts, including in low- and middle-income countries, to mitigate the rapid spread of COVID-19 and related negative consequences.
Research Areas (11) (Note that the research areas are divided into three themes)
Structural inequities in the COVID-19 response and ethics
#1 Structural Inequalities
Develop, implement and/or evaluate community-driven solutions to structural inequalities, including systemic racism, that continue to hamper the response and recovery from COVID-19 for Indigenous Peoples as well as Black and other communities marginalized by race.#2 Differential Impacts of COVID-19 on Historically Excluded or Underserved Populations
Understand and/or address the effects of the COVID-19 pandemic on Indigenous Peoples, racialized minorities, LGBTQIA2S, persons with disabilities, incarcerated individuals, children and older adults, including physical health, mental health, and access to health care services.#3 Urban Populations
Understand and/or address the impacts of COVID-19 on the health and well-being of urban populations, including those who have been historically excluded and underserved (e.g. homeless populations and Indigenous Peoples).#4 Healthcare Resource Allocation
Research on ethical criteria for scarce healthcare resource allocation (e.g., ICUs, ventilators, PPEs, vaccine) in a public health emergency to inform the development of national triage protocols. Research to understand and/or address equity in access to proven COVID-19 interventions and health services internationally and the ethical implications of vaccine nationalism for LMICs.#5 HIV and SARS-CoV-2
Understand the underlying biological interactions between HIV and SARS-CoV-2 co-infection as it relates to (1) the impacts of living with HIV on SARS-CoV-2 infection, including effect of HIV and/or antiretroviral treatment on mutation, evolution and fitness of SARS CoV-2, COVID-19 disease severity, development of post-COVID-19 conditions, and COVID-19 vaccine safety, efficacy, and long-term durability of the immune response to SARS-CoV-2, and/or (2) the impacts of SARS-CoV-2 infection on people living with HIV as it relates to treatment response, disease progression and development of co-morbidities; and/or understand how public health and infection control measures in response to COVID-19 have impacted the underlying social and behavioral factors affecting the risk of infection with HIV and other STBBI, and access to prevention, testing and treatment services for HIV and STBBI, including in remote locations or Indigenous communities. [Supported by the CIHR HIV/AIDS Research Initiative]
Ongoing impact of COVID-19 in health systems and services
#6 Health care systems and services
Understand and address the impact of COVID-19 on health care systems and services including developing and implementing evidence-based interventions (policy, practice and/or models of care) to minimize harms, address backlogs, and effectively address unmet needs during and after the pandemic, including those experienced by historically excluded or underserved populations.# 7 Support Services and Rehabilitation Strategies for Historically Excluded or Underserved Populations
Research on models of support services and clinical care / management and rehabilitation strategies, including for historically excluded or underserved populations (e.g. First Nations, Inuit, Métis or Urban Indigenous Peoples, persons with disabilities, immigrants and refugees, or other groups who have been disproportionately affected by COVID-19) experiencing post COVID-19 condition in the Canadian context.
Societal reopening in the context of COVID-19
#8 Immune Responses
Understand and improve immune responses to vaccines (immunobridging, annual boosters, boosters against variants, heterologous prime-boost); long term immune responses of SARS-CoV-2 infection and vaccination and duration of protection; and rate of vaccinated people developing severe diseases (1-2 doses) due to variants infection or difference in immune response.#9 Social and Behavioural Science Approaches
Develop, implement and/or evaluate social and behavioural science approaches to inform interventions that will be needed to help people adjust to a non-pandemic situation. Targeted interventions will be needed for all age groups and all demographics: older adults, adults, and children, as well as socio-economic, geographic and cultural backgrounds (e.g. Northern contexts, rural or on-reserve vs urban, lower SES neighbourhoods).#10 Core Public Health and Control Measures
Are the core public health and control measures (e.g. ventilation, movement restrictions) adequate/appropriate? Implementation science to inform scale up/adaptation of effective approaches to prevent future infections and outbreaks in high risk settings (childcare settings, schools, workplaces, jails, acute and long-term care settings, among migrant workers, homeless shelters, First Nations reserves). These include regular screening strategies, science communication, and/or roll out of mitigation plans in the case of isolated new cases.#11 Vaccine Distribution Models
Identify and evaluate the best methods for vaccine distribution to both "hard to reach" and those at risk of accelerating community spread, particularly among children, taking a holistic approach that considers barriers and facilitators at the individual, family, community, provincial and structural levels.
