To unravel the dynamics of transmission and selection of antimicrobial resistance (AMR) at the genetic, bacterial, animal, human, societal, and environmental levels, in order to design and evaluate preventive and intervening measures for controlling resistance.
The primary aim of the JPIAMR is to combine the resources, infrastructures, and research strengths of multiple countries in order to address transmission of antibiotic resistance following a ‘One Health Approach’. The goal is to foster multinational research collaborations to add value to and to build upon the research conducted independently at national level and to work together to improve the control of resistant bacterial infections of clinical and/or veterinary importance only.
An organism develops resistance to a drug either by a gene mutation or by the acquisition of genetic components from another strain (i.e. transmission of resistance). Resistant organisms can multiply in the presence of a drug (i.e. selection of resistance traits) but without transmission, resistance would remain an isolated problem.
To understand the complex biological and environmental interactions that shape the spread of antibiotic resistance, we must identify and characterize the determinants that contribute to the spread of resistance in and between different reservoirs; including humans (sick and healthy people), animals (livestock, companion and wild animals) and the environment (indoor and outdoor).
Investigating the complex biology and epidemiology of selection and transmission of resistance is crucial in order to design preventive measures to address this public threat. The success and abundance of antibiotic resistant bacterial strains with particular public health importance should be determined through the development of risk assessment approaches that are based on the genomic repertoire of bacterial pathogens and the ecological constraints that determine their fitness in clinical, community, veterinary, and environmental settings.
For more information, please consult the Joint Programming Initiative on Antimicrobial Resistance website.