Nicholas Bel - Biotechnology PhD Defense

Event Date:

Thursday, August 22, 2024 - 1:00pm to 2:00pm EDT

Event Location:

CB 4058

Event Contact Name:

Brenda Magajna

Event Contact E-mail:

You are invite to attend the defense of Biotechnology PhD candidate, Nicholas Bel on Thursday, Aug. 22 at 1 p.m. in CB 4058 or on zoom.

Title: Role of Survivin and Sirtuin-1 in Antioxidant & Redox Response in ARPE-19 Cells

Summary: This study aims to investigate the role of oxidative stress and the ability to use natural antioxidant compounds as a means of reducing oxidative stress and mitigating further cellular damages in an in vitro model of age-related macular degeneration. Resveratrol, pterostilbene, lutein, punicalagin, loganin, chebulagic acid, beta-carotene, and zeaxanthin were investigated in the cell culture model as a means of offering cytoprotection to ARPE-19 in environments of chronic oxidative stress. The study used engineered CRISPR Knockdown cells to investigate the response of antioxidants on survivin and sirtuin-1 reduced human retinal cells (ARPE-19 cells).

Committee Members: Dr. Neelam Khaper (supervisor), Dr. Christine Gottardo, Dr. Zach Suntres, and Dr. Guangdong Yang (external)

Everyone is welcome.

Please contact Brenda Magajna at phd.ses@lakeheadu.ca for more information and the zoom link.

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