Dr. Greg Spivak
Dr. Greg Spivak is using chemistry to develop a unique line of anticancer drugs.
"While platinum metal drugs continue to occupy a prominent position in the arsenal of anticancer agents, they suffer from a number of drawbacks," explains Dr. Spivak. As such, there is a solid need for alternative, metal-based anticancer compounds without such adverse shortcomings as high toxicity and solubility. To meet this demand, his team is currently investigating the plausibility of ruthenium-based drugs.
Ruthenium in general has long intrigued Dr. Spivak. In addition to chemotherapeutic applications, his lab has investigated the organometallic and catalytic chemistry of the metal, among other platinum group elements. In particular, he's interested in the metal's form, through which the synthesis and application of unique phosphine ligands can be explored as well as the potential for "zwitterionic" or neutrally charged ruthenium catalysts.
Positively charged catalysts are popularly used in industry. However, compared with their neutral counterparts, these catalysts can exhibit a diminished performance potential which can interfere with solvent and substrate compatibility. "Alternatively, a charge-neutral approach would help circumvent these problems and could lead to more efficient catalysts and possibly new catalytic applications."
Tackling projects like these, Dr. Spivak's students have an opportunity to delve deep into a research project, learn new techniques, and collaborate with other researchers. As well, the marketable skills students are provided will allow for a smooth transition into industrial careers.
In addition, Dr. Spivak makes a true effort to promote intellectual independence and encourage his students to take advantage of the immediate knowledge base that surrounds them.
"Students working in my lab should expect to broaden and enhance their synthetic chemistry, communication, and critical analysis skills, and to function independently." Simultaneously, he encourages his students to appreciate the value of collaboration and interdisciplinary research.